Adult PHN 150-300 mg daily in 2-3 divided doses. Initially 150 mg daily (75 mg bid or 50 mg tid), may be increased to 300 mg daily w/in 1 wk.
Management of pain associated w/ DPN Initially 150 mg daily in 3 divided doses, may be increased w/in 1 wk. Max dose: 300 mg daily in 3 divided doses.
Management of partial seizures 150-600 mg daily in 2-3 divided doses. Initially 75 mg bid or 50 mg tid. Max: 150 mg daily. Dose may be increased to 600 mg daily.
Management of fibromyalgia 300-450 mg daily. Initially 150 mg daily (75 mg bid), may be increased to 300 mg daily (150 mg bid) w/in 1 wk.
Renal impairment w/ total daily dose 600 mg in 2-3 divided doses CrCl 30-60 mL/min 300 mg 2-3 divided doses,
15-30 mL/min 150 mg in 1-2 divided doses,
<15 mL/min 75 mg as single daily dose;
total daily dose 450 mg in 2-3 divided doses CrCl 30-60 mL/min 225 mg in 2-3 divided doses,
15-30 mL/min 100-150 mg in 1-2 divided doses,
<15 mL/min 50-75 mg as single daily dose;
total daily dose 300 mg in 2-3 divided doses CrCl 30-60 mL/min 150 mg in 2-3 divided doses,
15-30 mL/min 75 mg in 1-2 divided doses,
<15 mL/min 25-50 mg as single daily dose;
total daily dose 150 mg in 2-3 divided doses CrCl 30-60 mL/min 75 mg in 2-3 divided doses,
15-30 mL/min 25-50 mg in 1-2 divided doses,
<15 mL/min 25 mg as single daily dose.
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